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PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps

Translocation of helicase-like proteins on nucleic acids underlies key cellular functions. However, it is still unclear how translocation can drive removal of DNA bound proteins, and basic properties like the elementary step size remain controversial. Using single molecule fluorescence analysis on a...

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Autori principali: Park, Jeehae, Myong, Sua, Niedziela-Majka, Anita, Yu, Jin, Lohman, Timothy M., Ha, Taekjip
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943210/
https://ncbi.nlm.nih.gov/pubmed/20723756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.016
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