PcrA-mediated disruption of RecA nucleoprotein filaments—essential role of the ATPase activity of RecA

The essential DNA helicase, PcrA, regulates recombination by displacing the recombinase RecA from the DNA. The nucleotide-bound state of RecA determines the stability of its nucleoprotein filaments. Using single-molecule fluorescence approaches, we demonstrate that RecA displacement by a translocati...

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Main Authors: Fagerburg, Matt V., Schauer, Grant D., Thickman, Karen R., Bianco, Piero R., Khan, Saleem A., Leuba, Sanford H., Anand, Syam P.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458574/
https://ncbi.nlm.nih.gov/pubmed/22743269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks641
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