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Alternative inhibition of androgen receptor signaling: Peptidomimetic pyrimidines as direct androgen receptor/coactivator disruptors

Compounds that directly disrupt the androgen receptor/steroid receptor coactivator interaction could function as novel inhibitors of androgen signaling that would remain effective in the treatment of prostate cancer that is resistant to conventional endocrine therapies. A structure-based peptidomime...

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Detalhes bibliográficos
Main Authors: Gunther, Jillian R., Parent, Alexander A., Katzenellenbogen, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941991/
https://ncbi.nlm.nih.gov/pubmed/19441848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900043e
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