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Partial restoration of T cell function in aged mice by in vitro blockade of the PD-1/PD-L1 pathway
Programmed death-1 (PD-1) is a newly characterized negative regulator of immune responses. The interaction of PD-1 with its ligands (PD-L1 and PD-L2) inhibits T cell proliferation and cytokine production in young mice. Increased PD-1 expression has been described during chronic infections, inducing...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941565/ https://ncbi.nlm.nih.gov/pubmed/20653631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2010.00611.x |
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