Differential control of CD4+ T cell subsets by the PD-1/PD-L1 axis in allergic asthma

Studies examining the role of PD-1 family members in allergic asthma have yielded conflicting results. Using a mouse model of allergic asthma, we find that blockade of PD-1/PD-L1 has distinct influences on different CD4+ T cell subsets. PD-1/PD-L1 blockade enhances AHR not by altering the magnitude...

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Vydáno v:Eur J Immunol
Hlavní autoři: McAlees, Jaclyn W., Lajoie, Stephane, Dienger, Krista, Sproles, Alyssa A., Richgels, Phoebe K., Yang, Yanfen, Khodoun, Marat, Azuma, Miyuki, Yagita, Hideo, Fulkerson, Patricia C., Wills-Karp, Marsha, Lewkowich, Ian P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440042/
https://ncbi.nlm.nih.gov/pubmed/25630305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444778
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