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Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice.

Maladaptive, Th2-polarized inflammatory responses are integral to the pathogenesis of allergic asthma. As regulators of T cell activation, dendritic cells (DCs) are important mediators of allergic asthma, yet the precise signals which render endogenous DCs "pro-asthmatic", and the extent t...

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Bibliografske podrobnosti
Main Authors: Ian P Lewkowich, Stephane Lajoie, Jennifer R Clark, Nancy S Herman, Alyssa A Sproles, Marsha Wills-Karp
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2008-01-01
Serija:PLoS ONE
Online dostop:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003879&type=printable
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