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Mapping Conformational Ensembles of Aβ Oligomers in Molecular Dynamics Simulations

Although the oligomers formed by Aβ peptides appear to be the primary cytotoxic species in Alzheimer's disease, detailed information about their structures appears to be lacking. In this article, we use exhaustive replica exchange molecular dynamics and an implicit solvent united-atom model to...

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Main Authors: Kim, Seongwon, Takeda, Takako, Klimov, Dmitri K.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941018/
https://ncbi.nlm.nih.gov/pubmed/20858441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.07.008
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