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Free Heme and the Polymerization of Sickle Cell Hemoglobin

In search of novel control parameters for the polymerization of sickle cell hemoglobin (HbS), the primary pathogenic event of sickle cell anemia, we explore the role of free heme, which may be excessively released in sickle erythrocytes. We show that the concentration of free heme in HbS solutions t...

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Bibliographische Detailangaben
Hauptverfasser: Uzunova, Veselina V., Pan, Weichun, Galkin, Oleg, Vekilov, Peter G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941010/
https://ncbi.nlm.nih.gov/pubmed/20858444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.07.024
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