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Liquid–liquid separation in solutions of normal and sickle cell hemoglobin

We show that in solutions of human hemoglobin (Hb)—oxy- and deoxy-Hb A or S—of near-physiological pH, ionic strength, and Hb concentration, liquid–liquid phase separation occurs reversibly and reproducibly at temperatures between 35 and 40°C. In solutions of deoxy-HbS, we demonstrate that the dense...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Galkin, Oleg, Chen, Kai, Nagel, Ronald L., Hirsch, Rhoda Elison, Vekilov, Peter G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2002
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC124280/
https://ncbi.nlm.nih.gov/pubmed/12070342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122055299
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