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Two-Step Mechanism of Homogeneous Nucleation of Sickle Cell Hemoglobin Polymers

Sickle cell anemia is a debilitating genetic disease that affects hundreds of thousands of babies born each year worldwide. Its primary pathogenic event is the polymerization of a mutant, sickle cell, hemoglobin (HbS); and this is one of a line of diseases (Alzheimer's, Huntington's, prion...

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Main Authors: Galkin, Oleg, Pan, Weichun, Filobelo, Luis, Hirsch, Rhoda Elison, Nagel, Ronald L., Vekilov, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913141/
https://ncbi.nlm.nih.gov/pubmed/17449671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.103705
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