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Metastable Mesoscopic Clusters in Solutions of Sickle-Cell Hemoglobin

Sickle cell hemoglobin (HbS) is a mutant, whose polymerization while in deoxy state in the venous circulation underlies the debilitating sickle cell anemia. It has been suggested that the nucleation of the HbS polymers occurs within clusters of dense liquid, existing in HbS solutions. We use dynamic...

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Detalhes bibliográficos
Main Authors: Pan, Weichun, Galkin, Oleg, Filobelo, Luis, Nagel, Ronald L., Vekilov, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697867/
https://ncbi.nlm.nih.gov/pubmed/17040989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.094854
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