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Metastable Polymerization of Sickle Hemoglobin in Droplets

Sickle cell disease arises from a genetic mutation of one amino acid in each of the two hemoglobin β chains, leading to the polymerization of hemoglobin in the red cell upon deoxygenation, and is characterized by vascular crises and tissue damage due to the obstruction of small vessels by sickled ce...

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Hlavní autoři: Aprelev, Alexey, Weng, Weijun, Zakharov, Mikhail, Rotter, Maria, Yosmanovich, Donna, Kwong, Suzanna, Briehl, Robin W., Ferrone, Frank A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950749/
https://ncbi.nlm.nih.gov/pubmed/17493634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.04.030
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