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Nucleation of Sickle Hemoglobin Mixed with Hemoglobin A: Experimental and Theoretical Studies of Hybrid-Forming Mixtures

Sickle hemoglobin (HbS) is a point mutation of the two β subunits in normal Hb (HbA) that leads to nucleated polymerization and accompanying pathology. We measured the rates of homogeneous and heterogeneous nucleation of HbS in the presence of up to 50% HbA under conditions in which hybrid HbAS mole...

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Bibliografski detalji
Glavni autori: Rotter, Maria, Yosmanovich, Donna, Briehl, Robin W., Kwong, Suzanna, Ferrone, Frank A.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297795/
https://ncbi.nlm.nih.gov/pubmed/22261068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.027
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