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Nucleation of Sickle Hemoglobin Mixed with Hemoglobin A: Experimental and Theoretical Studies of Hybrid-Forming Mixtures
Sickle hemoglobin (HbS) is a point mutation of the two β subunits in normal Hb (HbA) that leads to nucleated polymerization and accompanying pathology. We measured the rates of homogeneous and heterogeneous nucleation of HbS in the presence of up to 50% HbA under conditions in which hybrid HbAS mole...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3297795/ https://ncbi.nlm.nih.gov/pubmed/22261068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.027 |
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