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Heterogeneous Nucleation in Sickle Hemoglobin: Experimental Validation of a Structural Mechanism

Sickle hemoglobin polymerizes by two types of nucleation: homogeneous nucleation of aggregates in solution, and heterogeneous nucleation on preexisting polymers. It has been proposed that the same contact that is made in the interior of the polymer between the mutant site β6 and its receptor pocket...

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Hlavní autoři: Rotter, Maria A., Kwong, Suzanna, Briehl, Robin W., Ferrone, Frank A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Biophysical Society 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366768/
https://ncbi.nlm.nih.gov/pubmed/16055526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.067785
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