Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide

Antiepileptic drugs (AEDs) are frequently used to treat seizures in glioma patients. AEDs may have an unrecognized impact in modulating O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that has an important role in tumor cell resistance to alkylating agents. We report that levet...

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Detalhes bibliográficos
Main Authors: Bobustuc, George C., Baker, Cheryl H., Limaye, Arati, Jenkins, Wayne D., Pearl, Gary, Avgeropoulos, Nicholas G., Konduri, Santhi D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940696/
https://ncbi.nlm.nih.gov/pubmed/20525765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq044
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