TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT

BACKGROUND: Our previous studies have indicated that miR-198 reduces cellular methylguanine DNA methyltransferase (MGMT) levels to enhance temozolomide sensitivity. Transforming growth factor beta 1 (TGF-β1) switches off miR-198 expression by repressing K-homology splicing regulatory protein (KSRP)...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Nie, Er, Jin, Xin, Miao, Faan, Yu, Tianfu, Zhi, Tongle, Shi, Zhumei, Wang, Yingyi, Zhang, Junxia, Xie, Manyi, You, Yongping
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992894/
https://ncbi.nlm.nih.gov/pubmed/32813021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa198
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