WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

Wnt proteins are secreted post-translationally modified proteins that signal locally to regulate development and proliferation. The production of bioactive Wnts requires a number of dedicated factors in the secreting cell whose coordinated functions are not fully understood. A screen for small molec...

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Bibliografiska uppgifter
Huvudupphovsmän: Coombs, Gary S., Yu, Jia, Canning, Claire A., Veltri, Charles A., Covey, Tracy M., Cheong, Jit K., Utomo, Velani, Banerjee, Nikhil, Zhang, Zong Hong, Jadulco, Raquel C., Concepcion, Gisela P., Bugni, Tim S., Harper, Mary Kay, Mihalek, Ivana, Jones, C. Michael, Ireland, Chris M., Virshup, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Company of Biologists 2010
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939803/
https://ncbi.nlm.nih.gov/pubmed/20826466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.072132
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