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Essential Role for Vacuolar Acidification in Candida albicans Virulence
Fungal infections are on the rise, with mortality above 30% in patients with septic Candida infections. Mutants lacking V-ATPase activity are avirulent and fail to acidify endomembrane compartments, exhibiting pleiotropic defects in secretory, endosomal, and vacuolar pathways. However, the individua...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3764829/ https://ncbi.nlm.nih.gov/pubmed/23884420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494815 |
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