Autophagy extends lifespan via vacuolar acidification

Methionine restriction (MetR) is one of the rare regimes that prolongs lifespan across species barriers. Using a yeast model, we recently demonstrated that this lifespan extension is promoted by autophagy, which in turn requires vacuolar acidification. Our study is the first to place autophagy as on...

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Bibliografiske detaljer
Udgivet i:Microb Cell
Main Authors: Ruckenstuhl, Christoph, Netzberger, Christine, Entfellner, Iryna, Carmona-Gutierrez, Didac, Kickenweiz, Thomas, Stekovic, Slaven, Gleixner, Christina, Schmid, Christian, Klug, Lisa, Hajnal, Ivan, Sorgo, Alice G., Eisenberg, Tobias, Büttner, Sabrina, Marin͂o, Guillermo, Koziel, Rafael, Magnes, Christoph, Sinner, Frank, Pieber, Thomas R., Jansen-Dürr, Pidder, Fröhlich, Kai-Uwe, Kroemer, Guido, Madeo, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Shared Science Publishers OG 2014
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354602/
https://ncbi.nlm.nih.gov/pubmed/28357240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2014.05.147
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