WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

Wnt proteins are secreted post-translationally modified proteins that signal locally to regulate development and proliferation. The production of bioactive Wnts requires a number of dedicated factors in the secreting cell whose coordinated functions are not fully understood. A screen for small molec...

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Autori principali: Coombs, Gary S., Yu, Jia, Canning, Claire A., Veltri, Charles A., Covey, Tracy M., Cheong, Jit K., Utomo, Velani, Banerjee, Nikhil, Zhang, Zong Hong, Jadulco, Raquel C., Concepcion, Gisela P., Bugni, Tim S., Harper, Mary Kay, Mihalek, Ivana, Jones, C. Michael, Ireland, Chris M., Virshup, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2010
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939803/
https://ncbi.nlm.nih.gov/pubmed/20826466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.072132
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