UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy

BACKGROUND: The impact of thymidylate synthase (TYMS) and UDP-glucoronosyltransferase 1A (UGT1A) germline polymorphisms on the outcome of colorectal cancer (CRC) patients treated with irinotecan plus 5-fluorouracil (irinotecan/5FU) is still controversial. Our objective was to define a genetic-based...

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Autors principals: Martinez-Balibrea, E, Abad, A, Martínez-Cardús, A, Ginés, A, Valladares, M, Navarro, M, Aranda, E, Marcuello, E, Benavides, M, Massutí, B, Carrato, A, Layos, L, Manzano, J L, Moreno, V
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Genetics & Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939780/
https://ncbi.nlm.nih.gov/pubmed/20628391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605776
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