PKM2 Subcellular Localization Is Involved in Oxaliplatin Resistance Acquisition in HT29 Human Colorectal Cancer Cell Lines

Chemoresistance is the main cause of treatment failure in advanced colorectal cancer (CRC). However, molecular mechanisms underlying this phenomenon remain to be elucidated. In a previous work we identified low levels of PKM2 as a putative oxaliplatin-resistance marker in HT29 CRC cell lines and als...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ginés, Alba, Bystrup, Sara, Ruiz de Porras, Vicenç, Guardia, Cristina, Musulén, Eva, Martínez-Cardús, Anna, Manzano, José Luis, Layos, Laura, Abad, Albert, Martínez-Balibrea, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425499/
https://ncbi.nlm.nih.gov/pubmed/25955657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123830
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