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UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer
SN-38 is the active metabolite of irinotecan and it is metabolised through conjugation by uridine diphosphate glucuronosyl transferase (UGT1A1). The major toxicity of irinotecan therapy is diarrhoea, which has been related to the enzymatic activity of UGT1A1. We examined the influence of the UGT1A1...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2364770/ https://ncbi.nlm.nih.gov/pubmed/15280927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602042 |
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