UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

SN-38 is the active metabolite of irinotecan and it is metabolised through conjugation by uridine diphosphate glucuronosyl transferase (UGT1A1). The major toxicity of irinotecan therapy is diarrhoea, which has been related to the enzymatic activity of UGT1A1. We examined the influence of the UGT1A1...

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Bibliografiska uppgifter
Huvudupphovsmän: Marcuello, E, Altés, A, Menoyo, A, del Rio, E, Gómez-Pardo, M, Baiget, M
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2004
Ämnen:
Clinical
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364770/
https://ncbi.nlm.nih.gov/pubmed/15280927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602042
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