A genotype-directed phase I–IV dose-finding study of irinotecan in combination with fluorouracil/leucovorin as first-line treatment in advanced colorectal cancer

BACKGROUND: Infusional fluorouracil/leucovorin (FU/LV) plus irinotecan (FOLFIRI) is one of the standard first-line options for patients with metastatic colorectal cancer (mCRC). Irinotecan is converted into 7-ethyl-10-hydroxycamptothecin (SN-38) by a carboxylsterase and metabolised through uridine d...

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Detalhes bibliográficos
Main Authors: Marcuello, E, Páez, D, Paré, L, Salazar, J, Sebio, A, del Rio, E, Baiget, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137420/
https://ncbi.nlm.nih.gov/pubmed/21654688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.206
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