Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is an essential DNA repair protein that plays a critical role in repair of AP sites via base excision repair. Ape1 has received attention as a druggable oncotherapeutic target, especially for treating intractable cancers such as glioblastoma. The goal...

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Bibliographic Details
Main Authors: Bapat, Aditi, Glass, LaTeca S., Luo, Meihua, Fishel, Melissa L., Long, Eric C., Georgiadis, Millie M., Kelley, Mark R.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
Subjects:
Cellular and Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939666/
https://ncbi.nlm.nih.gov/pubmed/20504914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.169128
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