Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

β-catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and sequence diversity of Wnt isoforms suggest the possib...

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Detalhes bibliográficos
Main Authors: Gong, Yan, Bourhis, Eric, Chiu, Cecilia, Stawicki, Scott, DeAlmeida, Venita I., Liu, Bob Y., Phamluong, Khanhky, Cao, Tim C., Carano, Richard A. D., Ernst, James A., Solloway, Mark, Rubinfeld, Bonnee, Hannoush, Rami N., Wu, Yan, Polakis, Paul, Costa, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938341/
https://ncbi.nlm.nih.gov/pubmed/20856934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012682
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