Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.

Cytogenetic studies have previously identified abnormalities of chromosome band 11q23 in many cases of infant acute leukemia. Recent studies by ourselves and others have demonstrated breakpoint clustering in acute leukemias bearing translocations involving 11q23, and a Drosophila trithorax gene homo...

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Detalhes bibliográficos
Main Authors: Sorensen, P H, Chen, C S, Smith, F O, Arthur, D C, Domer, P H, Bernstein, I D, Korsmeyer, S J, Hammond, G D, Kersey, J H
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC293805/
https://ncbi.nlm.nih.gov/pubmed/8282816
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