Llwytho...
Role of the Residues of the 39-Loop in Determining the Substrate and Inhibitor Specificity of Factor IXa
The activation of antithrombin (AT) by heparin facilitates the exosite-dependent interaction of the serpin with factors IXa (FIXa) and Xa (FXa), thereby improving the rate of reactions by 300- to 500-fold. Relative to FXa, AT inhibits FIXa with ∼40-fold slower rate constant. Structural data suggest...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2010
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937874/ https://ncbi.nlm.nih.gov/pubmed/20628058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143321 |
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