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Factor Va alters the conformation of the Na(+)-binding loop of factor Xa in the prothrombinase complex
Structural and mutagenesis data have indicated that the 220-loop of thrombin is stabilized by a salt-bridge between Glu-217 and Lys-224, thereby facilitating the octahedral coordination of Na(+) with contributions from two carbonyl O atoms of Arg-221a and Lys-224. All three residues are also conserv...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440691/ https://ncbi.nlm.nih.gov/pubmed/18457426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800319r |
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