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Zymogenic and enzymatic properties of the 70–80 loop mutants of factor X/Xa

The Ca(2+) binding 70–80 loop of factor X (fX) contains one basic (Arg(71)) and three acidic (Glu(74), Glu(76), and Glu(77)) residues whose contributions to the zymogenic and enzymatic properties of the protein have not been evaluated. We prepared four Ala substitution mutants of fX (R71A, E74A, E76...

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Autori principali: Chen, Lin, Manithody, Chandrashekhara, Yang, Likui, Rezaie, Alireza R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286711/
https://ncbi.nlm.nih.gov/pubmed/14739327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03406904
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