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The functional significance of the autolysis loop in protein C and activated protein C

The autolysis loop of activated protein C (APC) is five residues longer than the autolysis loop of other vitamin K-dependent coagulation proteases. To investigate the role of this loop in the zymogenic and anticoagulant properties of the molecule, a protein C mutant was constructed in which the auto...

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Autors principals: Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1193704/
https://ncbi.nlm.nih.gov/pubmed/16113785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1267/THRO05010060
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