Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C

Substitution of the Gla-domain of activated protein C (APC) with the Gla-domain of prothrombin (APC-PTGla) improves the anticoagulant activity of APC independent of protein S. Previous FRET studies showed that this substitution alters the active-site topography of this mutant, rendering it identical...

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Bibliographic Details
Main Authors: Qureshi, Shabir H., Yang, Likui, Manithody, Chandrashekhara, Bae, Jong-Sup, Rezaie, Alireza R.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575086/
https://ncbi.nlm.nih.gov/pubmed/18539155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2008.05.004
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