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Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C
Substitution of the Gla-domain of activated protein C (APC) with the Gla-domain of prothrombin (APC-PTGla) improves the anticoagulant activity of APC independent of protein S. Previous FRET studies showed that this substitution alters the active-site topography of this mutant, rendering it identical...
Sparad:
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575086/ https://ncbi.nlm.nih.gov/pubmed/18539155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2008.05.004 |
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