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The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

Recent studies have indicated that activated protein C (APC) may exert its cytoprotective and anti-inflammatory activities through the endothelial protein C receptor (EPCR)-dependent cleavage of protease-activated receptor 1 (PAR-1) on vascular endothelial cells. Noting that (1) the activation of pr...

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Autori principali: Bae, Jong-Sup, Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190610/
https://ncbi.nlm.nih.gov/pubmed/17823308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-096651
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