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Activation of protein C by the thrombin–thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C

The binding of Ca(2+) to the 70–80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM. Structural data suggests that the 70–80 loop is located between two antiparallel β strands compris...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2006
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1347983/
https://ncbi.nlm.nih.gov/pubmed/16418283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507700103
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