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Activation of protein C by the thrombin–thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C
The binding of Ca(2+) to the 70–80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM. Structural data suggests that the 70–80 loop is located between two antiparallel β strands compris...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1347983/ https://ncbi.nlm.nih.gov/pubmed/16418283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507700103 |
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