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Activation of protein C by the thrombin–thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C

The binding of Ca(2+) to the 70–80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM. Structural data suggests that the 70–80 loop is located between two antiparallel β strands compris...

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Bibliografske podrobnosti
Main Authors: Yang, Likui, Manithody, Chandrashekhara, Rezaie, Alireza R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1347983/
https://ncbi.nlm.nih.gov/pubmed/16418283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507700103
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