The Identification of Histidine 712 as a Critical Residue for Constitutive TRPV5 Internalization

The epithelial Ca(2+) channel TRPV5 constitutes the apical entry gate for Ca(2+) transport in renal epithelial cells. Ablation of the trpv5 gene in mice leads to a reduced Ca(2+) reabsorption. TRPV5 is tightly regulated by various calciotropic hormones, associated proteins, and other factors, which...

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Bibliografiske detaljer
Main Authors: de Groot, Theun, Verkaart, Sjoerd, Xi, Qi, Bindels, René J. M., Hoenderop, Joost G. J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937873/
https://ncbi.nlm.nih.gov/pubmed/20628046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.117143
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