A Gate Hinge Controls the Epithelial Calcium Channel TRPV5

TRPV5 is unique within the large TRP channel family for displaying a high Ca(2+) selectivity together with Ca(2+)-dependent inactivation. Our study aims to uncover novel insights into channel gating through in-depth structure-function analysis. We identify an exceptional tryptophan (W583) at the ter...

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Publicado en:Sci Rep
Main Authors: van der Wijst, Jenny, Leunissen, Elizabeth H., Blanchard, Maxime G., Venselaar, Hanka, Verkaart, Sjoerd, Paulsen, Candice E., Bindels, René J., Hoenderop, Joost G.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379628/
https://ncbi.nlm.nih.gov/pubmed/28374795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45489
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