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Comparison of Solution and Crystal Properties of Co(II)-Substituted Human Carbonic Anhydrase II

The visible absorption of crystals of Co(II)-substituted human carbonic anhydrase II (Co(II)-HCA II) were measured over a pH range of 6.0 to 11.0 giving an estimate of pK(a) 8.4 for the ionization of the metal-bound water in the crystal. This is higher by about 1.2 pK(a) units than the pK(a) near 7....

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Bibliographic Details
Main Authors: Avvaru, Balendu Sankara, Arenas, Daniel J., Tu, Chingkuang, Tanner, D. B., McKenna, Robert, Silverman, David N.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937836/
https://ncbi.nlm.nih.gov/pubmed/20637176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.07.010
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