Inhibition of Encephalomyocarditis Virus and Poliovirus Replication by Quinacrine: Implications for the Design and Discovery of Novel Antiviral Drugs

The 9-aminoacridine (9AA) derivative quinacrine (QC) has a long history of safe human use as an antiprotozoal and antirheumatic agent. QC intercalates into DNA and RNA and can inhibit DNA replication, RNA transcription, and protein synthesis. The extent of QC intercalation into RNA depends on the co...

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Autors principals: Gasparian, Alexander V., Neznanov, Nickolay, Jha, Sujata, Galkin, Oleksandr, Moran, John J., Gudkov, Andrei V., Gurova, Katerina V., Komar, Anton A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937643/
https://ncbi.nlm.nih.gov/pubmed/20631142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02569-09
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