In Vitro Antiviral Activity of V-073 against Polioviruses

V-073, an enterovirus capsid inhibitor, was evaluated for its spectrum of antipoliovirus activity. V-073 inhibited all 45 polioviruses tested in a virus-induced cytopathic effect protection assay, with 50% effective concentration (EC(50)) values ranging from 0.003 to 0.126 μM. Ninety percent of the...

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Autors principals: Oberste, M. Steven, Moore, Deborah, Anderson, Barbara, Pallansch, Mark A., Pevear, Daniel C., Collett, Marc S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764203/
https://ncbi.nlm.nih.gov/pubmed/19635956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00671-09
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