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Control of Cholesterol Synthesis through Regulated ER-Associated Degradation of HMG CoA Reductase
Multiple mechanisms for feedback control of cholesterol synthesis converge on the rate-limiting enzyme in the pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase. This complex feedback regulatory system is mediated by sterol and nonsterol metabolites of mevalonate, the immediate product of redu...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937355/ https://ncbi.nlm.nih.gov/pubmed/20482385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2010.485605 |
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