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Control of Cholesterol Synthesis through Regulated ER-Associated Degradation of HMG CoA Reductase

Multiple mechanisms for feedback control of cholesterol synthesis converge on the rate-limiting enzyme in the pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase. This complex feedback regulatory system is mediated by sterol and nonsterol metabolites of mevalonate, the immediate product of redu...

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Bibliografische gegevens
Hoofdauteurs: Jo, Youngah, DeBose-Boyd, Russell A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937355/
https://ncbi.nlm.nih.gov/pubmed/20482385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2010.485605
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