Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization

Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor protein is linked to the development of several forms of cancer as well as oncogenic progression like sporadic renal clear-cell carcinomas (RCC). Despite the critical role played by VHL in destruction of hypoxia-inducible factor...

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Bibliographic Details
Main Authors: Cai, Qiliang, Robertson, Erle S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936558/
https://ncbi.nlm.nih.gov/pubmed/20844582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012636
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