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Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification
The hypoxic microenvironment contributes to embryonic development and tumor progression through stabilization of the potent transcriptional factor HIFα. In normoxia, the tumor suppressor protein VHL acts as an E3 ubiquitin ligase to target HIFα for proteolytic destruction. Increasing evidence shows...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2838797/ https://ncbi.nlm.nih.gov/pubmed/20300531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009720 |
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