SUMO-Modification of Human Nrf2 at K(110) and K(533) Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity

BACKGROUND/AIMS: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that binds to the antioxidant response element(s) (ARE) in target gene promoters, enabling oxidatively stressed cells to respond in order to restore redox homeostasis. Post-translational modifications (PTMs...

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Gepubliceerd in:Cell Physiol Biochem
Hoofdauteurs: Walters, Treniqka S., McIntosh, Deneshia J., Ingram, Shalonda M., Tillery, Lakeisha, Motley, Evangeline D., Arinze, Ifeanyi J., Misra, Smita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279473/
https://ncbi.nlm.nih.gov/pubmed/33770425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.33594/000000351
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