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SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability

The cancer-associated RNA-binding protein La is posttranslationally modified by phosphorylation and sumoylation. Sumoylation of La regulates not only the trafficking of La in neuronal axons but also its association with specific mRNAs. Depletion of La in various types of cancer cell lines impairs ce...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Kota, Venkatesh, Sommer, Gunhild, Hazard, E. Starr, Hardiman, Gary, Twiss, Jeffery L., Heise, Tilman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748460/
https://ncbi.nlm.nih.gov/pubmed/29084811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00129-17
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