Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

Here, we show that phosphatidylinositol 3-kinase (PI3K) is a key player in the establishment of central sensitization, the spinal cord phenomenon associated with persistent afferent inputs and contributing to chronic pain states. We demonstrated electrophysiologically that PI3K is required for the f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pezet, Sophie, Marchand, Fabien, D'Mello, Richard, Grist, John, Clark, Anna K., Malcangio, Marzia, Dickenson, Anthony H., Williams, Robert J., McMahon, Stephen B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2008
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935680/
https://ncbi.nlm.nih.gov/pubmed/18417706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5392-07.2008
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