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Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

Here, we show that phosphatidylinositol 3-kinase (PI3K) is a key player in the establishment of central sensitization, the spinal cord phenomenon associated with persistent afferent inputs and contributing to chronic pain states. We demonstrated electrophysiologically that PI3K is required for the f...

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書誌詳細
主要な著者: Pezet, Sophie, Marchand, Fabien, D'Mello, Richard, Grist, John, Clark, Anna K., Malcangio, Marzia, Dickenson, Anthony H., Williams, Robert J., McMahon, Stephen B.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935680/
https://ncbi.nlm.nih.gov/pubmed/18417706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5392-07.2008
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