Phosphatidylinositol 3-Kinase Is a Key Mediator of Central Sensitization in Painful Inflammatory Conditions

Here, we show that phosphatidylinositol 3-kinase (PI3K) is a key player in the establishment of central sensitization, the spinal cord phenomenon associated with persistent afferent inputs and contributing to chronic pain states. We demonstrated electrophysiologically that PI3K is required for the f...

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Bibliografiske detaljer
Main Authors: Pezet, Sophie, Marchand, Fabien, D'Mello, Richard, Grist, John, Clark, Anna K., Malcangio, Marzia, Dickenson, Anthony H., Williams, Robert J., McMahon, Stephen B.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2008
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935680/
https://ncbi.nlm.nih.gov/pubmed/18417706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5392-07.2008
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