P2X7-Dependent Release of Interleukin-1β and Nociception in the Spinal Cord following Lipopolysaccharide

The cytokine interleukin-1β (IL-1β) released by spinal microglia in enhanced response states contributes significantly to neuronal mechanisms of chronic pain. Here we examine the involvement of the purinergic P2X7 receptor in the release of IL-1β following activation of Toll-like receptor-4 (TLR4) i...

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Main Authors: Clark, Anna K., Staniland, Amelia A., Marchand, Fabien, Kaan, Timothy K. Y., McMahon, Stephen B., Malcangio, Marzia
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880485/
https://ncbi.nlm.nih.gov/pubmed/20071520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3295-09.2010
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