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NMDA receptor activation modulates evoked release of substance P from rat spinal cord

The possible modulation exerted by glutamate on substance P (SP) release from the rat spinal cord has been investigated. The N-methyl-D-aspartate (NMDA) receptor agonist, NMDA (1 μM), increased SP basal outflow by 46.5±10.9% (n=3, P<0.01) without changing the evoked release of the peptide. Conver...

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Detalhes bibliográficos
Main Authors: Malcangio, Marzia, Fernandes, Karin, Tomlinson, David R
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565764/
https://ncbi.nlm.nih.gov/pubmed/9886751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702260
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